I-CAS 71686-01-6 Calcium Alpha Ketoglutarate

I-calcium Alpha-Ketoglutate Alpha ibizwa nangokuthi i-ketoglutaric acid (α-ketoglutaric acid), ifomula yamakhemikhali C5h6o5, elinye lama-derivatives amabili okususelwa eqenjini le-glutaric acid, i-White Crystalline powder. Usawoti wayo uyindawo ebalulekile yemvelo. I-α-ketoglutaric acid ibamba iqhaza kumjikelezo we-tricarboxylic acid ezintweni eziphilayo, futhi iyi-metabolite ephakathi ye-tricarboxylic acid umjikelezo we-tricarboxylic acid, ukubamba iqhaza ekuhlolweni kwama-amino acid, amavithamini kanye nama-organic acid namandla e-Metabolism. Ingasetshenziswa njengesengezo sokudla, futhi inezinhlobonhlobo zamathemba wohlelo lokusebenza.

Umsebenzi wohlelo lokusebenza

Umjikelezo we-tricarboxylic acid

I-α-Ketoglutarate ingumphakathi obalulekile we-metabolic ku-tricarboxylic acid umjikelezo wama-microorganisms, futhi kuyindlela ebalulekile yokuxhuma i-metabolism ye-carbon-nitrogen ye-intracellular. Itholakala ngemuva kwe-isocitric acid futhi ngaphambi kokuthi i-Sucnyl Coenzyme a in umjikelezo. Kuleli sayithi, ukusabela okwenziwa emuva kungatholakala ukuze kugcwaliswe le metabolite ephakathi ngokukhiqizwa kwe-α-ketoglutarate ngokudluliselwa kwe-auhyrogenate, kanye nangesenzo se-glutamate dehydrogenase ku-glutamate. [2]

Ukukhiqizwa kwe-amino acid powder

I-glutamate ikhiqizwa i-glutamine synthase, esebenzisa i-molecule ye-ATP ukukhiqiza i-glutamyyl foni; Lo mphakathi uhlaselwa yi-ammonia, esebenza njenge-realent ye-nucleophilic, okuholela ekwakhekeni kwe-glutamine ne-inorganic phosphate.

Izithasiselo Zokudla

I-Alpha-Ketoglutarate iyathengiswa njengezinye izithasiselo zokudla ngaphansi kwegama lezohwebo akg noma i-A-kg kubathandi bokuqina noma abakhiqizi bokwakha, abathi into ithuthukisa ukusebenza esilinganisweni sokuqeqeshwa. Lokhu bekufunwa ukuthi kususelwa "ekucwaningeni okubonisa ukuthi i-ammonia ngokweqile ingabopha i-alpha-ketoglutarate futhi isuswe ukunciphisa izinkinga eziningi ezihambisana ne-ammonia ubuthi". Kodwa-ke, okuwukuphela kwezifundo ezikhombise i-Alpha-Ketoglutarate ukuze zisebenze ngempumelelo ekunciphiseni ubuthi be-ammonia kube ezigulini ezise-hemodialysis.

I-KetoGlutaric Acid Calculator (Alpha Ketoglutaricid Calculator) iyisigameko esikhiqizwe yi-ATP noma i-GTP kumjikelezo we-KREBS. I-2-Ketoglutaric acid calcium futhi isebenza njenge-carbon backmbone eyinhloko yokuphendula okuhlanganayo kwe-nitrogen. I-2-Ketoglutaric acid calcium iyinhlangano eguquguqukayo ye-tyrosinase (IC50 = 15 mm).

Ukuchazwa Komkhiqizo

Igama lomkhiqizo: I-Calcium Alpha Ketoglutarate

I-CAS NO: 71686-01-6

Ifomula ye-Molecular: C5h8CAO5

Isisindo Molecular: 188.19

EInecs No.: 275-843-2

MDL No.:MFCD02683879

Iphoyinti Lokuncibilika:> 300 ° C

Isitoreji Isimo: -20 ° C

Ukumsulwa: 98%